IL1R1/IL1RAP Human Interleukin Cell Based Agonist Dimerization LeadHunter Assay - US

Background Information:

The PathHunter® Dimerization assay detects ligand induced dimerization of two subunits of a receptor-dimer pair. The cells have been engineered to co-express one receptor subunit fused to Enzyme Donor (ED), and a second dimer partner fused to Enzyme Acceptor (EA). Cytoplasmic tail may have been deleted from one or both receptors. Binding of an agonist to one receptor subunit induces it to interact with its dimer partner, forcing complementation of the two enzyme fragments. This results in the formation of a functional enzyme that hydrolyzes a substrate to generate a chemiluminescent signal.

Family:

Cell Surface (Other)

Sub Family:

Cytokine

Class:

IL-1

Protein Name:

IL1R1

Uniprot Number:

P14778

Protein Aliases:

IL-1RT-1|IL-1RT1|CD121 antigen-like family member A|Interleukin-1 receptor alpha|IL-1R-alpha|Interleukin-1 receptor type I|p80|CD antigen CD121a [Cleaved into: Interleukin-1 receptor type 1, membrane form|mIL-1R1|mIL-1RI; Interleukin-1 receptor type 1, soluble form|sIL-1R1|sIL-1RI]

Gene Name:

IL1R1

Gene ID:

3554

Gene Aliases:

IL1R|IL1RA|IL1RT1

Accession Number:

NM_000877.3

Organism:

Human

Cell Type:

U2OS