IL31RA/OSMR Human Interleukin Cell Based Agonist Dimerization LeadHunter Assay - US

Background Information:

The PathHunter® Dimerization assay detects ligand induced dimerization of two subunits of a receptor-dimer pair. The cells have been engineered to co-express one receptor subunit fused to Enzyme Donor (ED), and a second dimer partner fused to Enzyme Acceptor (EA). Cytoplasmic tail may have been deleted from one or both receptors. Binding of an agonist to one receptor subunit induces it to interact with its dimer partner, forcing complementation of the two enzyme fragments. This results in the formation of a functional enzyme that hydrolyzes a substrate to generate a chemiluminescent signal.

Family:

Cell Surface (Other)

Sub Family:

Cytokine

Class:

IL-6

Protein Name:

IL31RA

Uniprot Number:

Q8NI17

Protein Aliases:

IL-31R subunit alpha|IL-31R-alpha|IL-31RA|Cytokine receptor-like 3|GLM-R|hGLM-R|Gp130-like monocyte receptor|Gp130-like receptor|ZcytoR17

Gene Name:

IL31RA

Gene ID:

133396

Gene Aliases:

CRL3|GPL|UNQ6368/PRO21073/PRO21384

Accession Number:

NM_139017.5

Organism:

Human

Cell Type:

U2OS