LPA1 Human Lysophospholipid (LPA) GPCR Cell Based Agonist Activated Internalization LeadHunter Assay - US

Background Information:

PathHunter Activated GPCR Internalization cell lines are engineered to co-express an untagged GPCR, Enzyme Acceptor (EA) tagged β-Arrestin, and a ProLink™ (PK) tag localized to the endosomes. Activation of the GPCR induces β-Arrestin recruitment, followed by internalization of the Receptor/Arrestin-EA complex in PK-tagged endosomes. This forces complementation of the two β-galactosidase enzyme fragments (EA and PK), forming functional enzyme that hydrolyzes substrate to generate a chemiluminescent signal.

Family:

GPCR

Sub Family:

Lysophospholipid (LPA)

Class:

Class A

Coupling:

Gi/Go & Gq

Protein Name:

LPA1

Uniprot Number:

Q92633

Protein Aliases:

LPA-1|EDG2|Lysophosphatidic acid receptor Edg-2

Gene Name:

LPAR1

Gene ID:

1902

Gene Aliases:

edg-2|rec.1.3|vzg-1|Gpcr26|Mrec1.3|LPA1|GPR26

Accession Number:

NM_001401.3

Organism:

Human

Cell Type:

U2OS