LPA1 Human Lysophospholipid (LPA) GPCR Cell Based Antagonist Calcium Flux (in Arrestin Cell Line) LeadHunter Assay - US

Background Information:

PathHunter β-Arrestin GPCR cell lines are engineered to co-express the ProLink™ (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged β-Arrestin. Activation of the GPCR-PK induces β-Arrestin-EA recruitment, forcing complementation of the two enzyme fragments. The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. PathHunter cell lines expressing Gq-coupled receptors can also be used to detect calcium mobilization.

Family:

GPCR

Sub Family:

Lysophospholipid (LPA)

Class:

Class A

Coupling:

Gi/Go & Gq

Protein Name:

LPA1

Uniprot Number:

Q92633

Protein Aliases:

LPA-1|EDG2|Lysophosphatidic acid receptor Edg-2

Gene Name:

LPAR1

Gene ID:

1902

Gene Aliases:

edg-2|rec.1.3|vzg-1|Gpcr26|Mrec1.3|LPA1|GPR26

Accession Number:

NM_001401.3

Organism:

Human

Cell Type:

CHO-K1