MC1 Human Melanocortin GPCR Cell Based Agonist cAMP LeadHunter Assay - US

Background Information:

Melanocortin receptors (MCRs) belong to the superfamily of seven transmembrane G-protein-coupled receptors, which constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The melanocortin system and their receptors are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis, sexual function and temperature control. The melanocortin MC1 receptor is made primarily in melanocytes, MC2 in adrenal cortex, MC3 and MC4 almost exclusively neuronal, and MC5 in exocrine gland cells. Melanocortin MC1 receptor agonism may increase the risk of developing melanoma and nonmelanoma skin cancer beyond their effects on pigmentation phenotype.

cAMP Hunter™ Gs cell lines overexpress naturally Gs coupled, wild type GPCRs and are designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Melanocortin

Class:

Class A

Coupling:

Gs

Protein Name:

MC1

Uniprot Number:

Q01726

Protein Aliases:

alpha melanocyte stimulating hormone receptor

Gene Name:

MC1R

Gene ID:

4157

Gene Aliases:

MSH-R|MSHR

Accession Number:

NM_002386

Organism:

Human

Cell Type:

CHO-K1