MCH2 Human Melanin-Conc. Hormone GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR

Background Information:

The human melanin-concentrating hormone receptor is a member of the G protein coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The melanin-concentrating hormone receptor 2 (MCH2) binds the melanin-concentrating hormone, a cyclic orexinogenic peptide. MCH2 is predominantly expressed in the central nervous system and plays an important role in feeding behavior and energy balance, particularly metabolic homeostasis.

Family:

GPCR

Sub Family:

Melanin-Concentrating Hormone

Class:

Class A

Protein Name:

MCH2

Uniprot Number:

Q969V1

Protein Aliases:

MCH-R2|MCHR-2|G-protein coupled receptor 145|GPRv17|MCH-2R|MCH2|MCH2R

Gene Name:

MCHR2

Gene ID:

84539

Gene Aliases:

SLT|MCH2|MCH2R

Accession Number:

NM_032503

Organism:

Human

Construct Details:

Recombinant

Cell Type:

CHO-K1