mu (MOP) Human Opioid GPCR Cell Based PAM cAMP LeadHunter Assay - US

Background Information:

Opiates exert their effects in the central and peripheral nervous systems through interaction with m, k and d, three major types of opioid receptors, which are structural homologues and belong to the G protein-coupled receptor (GPCR) family. G-protein cascades activated by these three receptors can reduce adenylyl cyclase activity, alter inositol trisphosphate turnover, activate G-protein-linked, inward potassium channels, and close calcium channels. These receptors mediate the actions of opiate drugs and endogenous opioid neuropeptides in producing euphoria, modulating pain perception, and altering other important functions in the central and peripheral nervous systems.

cAMP Hunter™ Gi cell lines overexpress naturally Gi coupled, wild type GPCRs and are designed to detect inhibition of intracellular cAMP production in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Opioid

Class:

Class A

Protein Name:

mu (MOP)

Uniprot Number:

P35372

Protein Aliases:

MOR-1|Mu opiate receptor|Mu opioid receptor|MOP|hMOP

Gene Name:

OPRM1

Gene ID:

4988

Gene Aliases:

MOR1

Accession Number:

NM_000914.3

Organism:

Human

Cell Type:

CHO-K1