Nav1.5 Human Sodium Ion Channel (Batrachotoxin site 2) Mass Spectrometry Binding LeadHunter Assay - FR

Background Information:

Sodium channels are the founding members of the superfamily of ion channels that include voltage-gated potassium and calcium channels. Unlike the different classes of potassium and calcium channels, however, the functional properties of the known sodium channels (NaV) are relatively similar. Voltage-gated Sodium Site 2 channels, found in central neurons primarily localized to unmyelinated and pre-myelinated axons, govern action, potential initiation, and repetitive firing. Consequently, antagonists may be antiepileptic and antiarrhythmic as well as proarrhythmic; agonists may also cause cardiac arrhythmia. Nav1.5 is the isoform related to cardiovascular toxicity and is recommended for safety pharmacology profiling.

Family:

Ion Channel

Sub Family:

Sodium

Class:

Voltage-Gated

Protein Name:

Nav1.5

Uniprot Number:

Q14524 (human)

Protein Aliases:

Sodium channel protein cardiac muscle subunit alpha,Sodium channel protein type V subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.5

Gene Name:

SCN5A

Gene ID:

6331

Gene Aliases:

HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5

Organism:

Human