P300 Human Histone Acetyltransferase (HAT) Enzymatic LeadHunter Assay - TW

Background Information:

Histone acetyltransferases (HAT) are enzymes that covalently modify the N-terminal lysine of all four core histones in nucleosomes by the addition of acetyl groups from acetyl-CoA. HAT enzymes regulate transcription via chromatin remodeling; HAT’s are recruited on to the chromatin template and transcription is enhanced by acetylation of promoter proximal nucleosomal histones. Upon acetylation the histone complex relaxes facilitating other proteins to act on the DNA. P300 acetylase activity is not limited to histones since it can also acetylate non histone targets like p53 and ERa. P300 directly interacts with transcription factors and acts as a global transcriptional coactivator; it plays a critical role in a variety of cellular process including cell cycle control, differentiation, and apoptosis. P300 deregulation is believed to play an important role in Cancer.

Family:

Epigenetic

Sub Family:

Histone Acetyltransferase (HAT)

Class:

Writer

Protein Name:

P300

Uniprot Number:

Q09472

Protein Aliases:

histone acetyltransferase p300

Gene Name:

EP300

Gene ID:

2033

Gene Aliases:

p300|KAT3B

Accession Number:

NM_001429

Organism:

Human

Construct Details:

Fragment (1284-1673), Recombinant