PAF Human Platelet-Activating Factor GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR

Background Information:

PAF receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. PAF receptors are found in a diverse array of cells, including neutrophilic polymorphonuclear leukocytes (PMN), platelets, mast cells, monocytes/macrophages, vascular endothelial cells and lymphocytes. PAF receptor stimulation is involved in intracrine, autocrine, paracrine and juxtacrine cell activation.

Family:

GPCR

Sub Family:

Platelet-Activating Factor

Class:

Class A

Protein Name:

PAF

Uniprot Number:

P25105

Protein Aliases:

PAFr

Gene Name:

PTAFR

Gene ID:

5724

Accession Number:

NM_000952

Organism:

Human

Construct Details:

Recombinant

Cell Type:

Chem-1