PKA Human AGC Kinase Enzymatic Radiometric [Km ATP] LeadHunter Assay - FR

Background Information:

Cyclic-AMP exerts its effects in animal cells mainly by activating the enzyme cyclic AMP-dependent protein kinase A (PKA). This enzyme catalyzes transfer of the terminal phosphate group from ATP to specific serines and threonines of selected proteins. Covalent phosphorylation of the appropriate amino acids of specific cellular proteins in turn results in altered cellullar function as a consequence of activation or inactivation of enzymes or altered membrane permeability to ions or other possible effects. PKA is found in all animal cells, and it is known that hormones or transmitters may be mediated by cAMP-stimulated phosphorylation of specific sites on neuronal or non-neuronal cells to exert their physiological function.

Family:

Kinase

Sub Family:

AGC

Class:

Protein Ser/Thr

Protein Name:

PKACalpha

Uniprot Number:

P17612

Gene Name:

PRKACA

Gene ID:

5566

Accession Number:

X07767

Organism:

Human