PTH1 Human Parathyroid Hormone GPCR Cell Based Agonist Arrestin LeadHunter Assay - US

Background Information:

PathHunter β-Arrestin GPCR cell lines are engineered to co-express the ProLink™ (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged β-Arrestin. Activation of the GPCR-PK induces β-Arrestin-EA recruitment, forcing complementation of the two enzyme fragments. The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. PathHunter cell lines expressing Gq-coupled receptors can also be used to detect calcium mobilization.

Family:

GPCR

Sub Family:

Parathyroid Hormone

Class:

Class B

Coupling:

Gs & Gq

Protein Name:

PTH1

Uniprot Number:

Q03431

Protein Aliases:

PTH/PTHr receptor|Parathyroid hormone 1 receptor|PTH1 receptor

Gene Name:

PTH1R

Gene ID:

5745

Accession Number:

AY449732

Organism:

Human

Cell Type:

CHO-K1