Ret (G810R) Human RTK Kinase KINOMEscan ELECT Binding LeadHunter Assay - US

Background Information:

The RET (rearranged during transfection) receptor tyrosine kinase is a classic example of phenotype heterogeneity. Gain-of-function mutations of RET are associated with human cancer and multiple endocrine neoplasia type 2 (MEN 2A, MEN 2B, etc.) Loss-of-function mutations of RET cause Hirschspung disease or colonic aganglionosis).

Family:

Kinase

Sub Family:

RTK

Class:

Protein Tyrosine

Protein Name:

Ret

Uniprot Number:

P07949

Protein Aliases:

cadherin-related family member 16|RET receptor tyrosine kinase|rearranged during transfection

Gene Name:

RET

Gene ID:

5979

Gene Aliases:

PTC|CDHF12|RET51|CDHR16

Accession Number:

NP_065681.1

Organism:

Human

Construct Details:

Mutation (G810R); Partial Length (Start/Stop: E713/D1014); Bacterial Expression