OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Targets: 47
Target Families: Kinases (4), GPCRs (24), NHRs (2), Ion Channels (8), Transporters (3), Non-Kinase Enzymes (6)
Testing: In vitro secondary pharmacology for early derisking, off-target mitigation, and prioritization
Results: 10-point (3-fold) dose-response curves; EC50, IC50, Kd values (where feasible)
For more info, see the DOCUMENTS/REFERENCES tab above
No. of Assays on Panel:
78
Assays on Panel:
Family
Kinase
Name
Lck Human TK Kinase Binding SAFETYscan SafetyScreen Assay - US
Item
87-1002-1050
Protein
Lck
Organism
Human
Assay Sub Type
Binding
Family
Kinase
Name
KDR (VEGFR2) Human RTK Kinase Binding SAFETYscan SafetyScreen Assay - US
Item
87-1002-1069
Protein
KDR (VEGFR2)
Organism
Human
Assay Sub Type
Binding
Family
Kinase
Name
IR (INSR) Human RTK Kinase Binding SAFETYscan SafetyScreen Assay - US
Item
87-1002-1197
Protein
IR
Organism
Human
Assay Sub Type
Binding
Family
Kinase
Name
ROCK1 Human AGC Kinase Binding SAFETYscan SafetyScreen Assay - US
Item
87-1002-1437
Protein
ROCK1
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
DAT Human Dopamine Transporter Functional Antagonist Uptake SAFETYscan SafetyScreen Assay - US
Item
87-1002-1535AN
Protein
DAT
Organism
Human
Assay Sub Type
Cell Based
Family
Transporter
Name
NET Human Norepinephrine Transporter Functional Antagonist Uptake SAFETYscan SafetyScreen Assay - US
Item
87-1002-1536AN
Protein
NET
Organism
Human
Assay Sub Type
Cell Based
Family
Transporter
Name
SERT Human Serotonin Transporter Functional Antagonist Uptake SAFETYscan SafetyScreen Assay - US
Item
87-1002-1537AN
Protein
SERT
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
GABAA (alpha1/beta2/gamma2) Human Ion Channel Cell Based Agonist Membrane Potential SAFETYscan SafetyScreen Assay - US
Item
87-1002-1538AG
Protein
GABAA
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
GABAA (alpha1/beta2/gamma2) Human Ion Channel Cell Based Antagonist Membrane Potential SAFETYscan SafetyScreen Assay - US
Item
87-1002-1538AN
Protein
GABAA
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
5-HT3A Human Serotonin Ion Channel Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-1539AG
Protein
5-HT3A
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
5-HT3A Human Serotonin Ion Channel Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-1539AN
Protein
5-HT3A
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
Cav1.2 (L-type) Human Calcium Ion Channel Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-1540AN
Protein
Cav1.2 (L-type)
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
hERG Human Potassium Ion Channel Cell Based Antagonist Thallium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-1541AN
Protein
hERG
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
KCNQ1 KvLQT1/minK Human Potassium Ion Channel Cell Based Agonist Thallium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-1542AG
Protein
KCNQ1
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
KCNQ1 KvLQT1/minK Human Potassium Ion Channel Cell Based Antagonist Thallium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-1542AN
Protein
KCNQ1
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
Nav1.5 Human Sodium Ion Channel Cell Based Antagonist Membrane Potential SAFETYscan SafetyScreen Assay - US
Item
87-1002-1543AN
Protein
Nav1.5
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
NMDAR (1A/2B) Human Glutamate (Ionotropic) Ion Channel Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-1544AG
Protein
GluN1 (NMDAR)
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
NMDAR (1A/2B) Human Glutamate (Ionotropic) Ion Channel Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-1544AN
Protein
GluN1 (NMDAR)
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
nAChR (alpha4/beta2) Human Ion Channel Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-1545AG
Protein
nAChR
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
nAChR (alpha4/beta2) Human Ion Channel Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-1545AN
Protein
nAChR
Organism
Human
Assay Sub Type
Cell Based
Family
Lipid Metabolism
Name
COX1 Human Cyclooxygenase Enzymatic SAFETYscan SafetyScreen Assay - US
Item
87-1002-1546AN
Protein
COX1
Organism
Human
Assay Sub Type
Enzymatic
Family
Lipid Metabolism
Name
COX2 Human Cyclooxygenase Enzymatic SAFETYscan SafetyScreen Assay - US
Item
87-1002-1547AN
Protein
COX2
Organism
Human
Assay Sub Type
Enzymatic
Family
Neurotransmitter Metabolism
Name
Acetylcholinesterase Human Enzymatic SAFETYscan SafetyScreen Assay - US
Item
87-1002-1548AN
Protein
Acetylcholinesterase
Organism
Human
Assay Sub Type
Enzymatic
Family
Neurotransmitter Metabolism
Name
Monoamine Oxidase A (MAO-A) Human Enzymatic SAFETYscan SafetyScreen Assay - US
Item
87-1002-1549AN
Protein
Monoamine Oxidase A (MAO-A)
Organism
Human
Assay Sub Type
Enzymatic
Family
PDE
Name
PDE3A Human Phosphodiesterase Enzymatic SAFETYscan SafetyScreen Assay - US
Item
87-1002-1550AN
Protein
PDE3A
Organism
Human
Assay Sub Type
Enzymatic
Family
PDE
Name
PDE4D Human Phosphodiesterase Enzymatic SAFETYscan SafetyScreen Assay - US
Item
87-1002-1551AN
Protein
PDE4D
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
5-HT2A Human Serotonin GPCR Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2090AG
Protein
5-HT2A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT2A Human Serotonin GPCR Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2090AN
Protein
5-HT2A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT2B Human Serotonin GPCR Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2091AG
Protein
5-HT2B
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT2B Human Serotonin GPCR Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2091AN
Protein
5-HT2B
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
M1 Human Acetylcholine (Muscarinic) GPCR Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2095AG
Protein
M1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
M1 Human Acetylcholine (Muscarinic) GPCR Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2095AN
Protein
M1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
M3 Human Acetylcholine (Muscarinic) GPCR Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2097AG
Protein
M3
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
M3 Human Acetylcholine (Muscarinic) GPCR Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2097AN
Protein
M3
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2120AG
Protein
CB2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2120AN
Protein
CB2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CCK1 (CCKA) Human Cholecystokinin GPCR Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2138AG
Protein
CCK1 (CCKA)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CCK1 (CCKA) Human Cholecystokinin GPCR Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2138AN
Protein
CCK1 (CCKA)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
ETA Human Endothelin GPCR Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2157AG
Protein
ETA
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
ETA Human Endothelin GPCR Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2157AN
Protein
ETA
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
H1 Human Histamine GPCR Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2171AG
Protein
H1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
H1 Human Histamine GPCR Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2171AN
Protein
H1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
V1A Human Vasopressin / Oxytocin GPCR Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2239AG
Protein
V1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
V1A Human Vasopressin / Oxytocin GPCR Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2239AN
Protein
V1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT1A Human Serotonin GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2261AG
Protein
5-HT1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT1A Human Serotonin GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2261AN
Protein
5-HT1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT1B Human Serotonin GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2262AG
Protein
5-HT1B
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT1B Human Serotonin GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2262AN
Protein
5-HT1B
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
M2 Human Acetylcholine (Muscarinic) GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2265AG
Protein
M2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
M2 Human Acetylcholine (Muscarinic) GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2265AN
Protein
M2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
alpha2A Human Adrenoceptor GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2270AG
Protein
alpha2A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
alpha2A Human Adrenoceptor GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2270AN
Protein
alpha2A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
beta1 Human Adrenoceptor GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2272AG
Protein
beta1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
beta1 Human Adrenoceptor GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2272AN
Protein
beta1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
beta2 Human Adrenoceptor GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2273AG
Protein
beta2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
beta2 Human Adrenoceptor GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2273AN
Protein
beta2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CB1 Human Cannabinoid GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2277AG
Protein
CB1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CB1 Human Cannabinoid GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2277AN
Protein
CB1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
D1 Human Dopamine GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2295AG
Protein
D1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
D1 Human Dopamine GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2295AN
Protein
D1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
D2S Human Dopamine GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2297AG
Protein
D2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
D2S Human Dopamine GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2297AN
Protein
D2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
H2 Human Histamine GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2315AG
Protein
H2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
H2 Human Histamine GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2315AN
Protein
H2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
delta (DOP) Human Opioid GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2339AG
Protein
delta (DOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
delta (DOP) Human Opioid GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2339AN
Protein
delta (DOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
kappa (KOP) Human Opioid GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2340AG
Protein
kappa (KOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
kappa (KOP) Human Opioid GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2340AN
Protein
kappa (KOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
mu (MOP) Human Opioid GPCR Cell Based Agonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2342AG
Protein
mu (MOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
mu (MOP) Human Opioid GPCR Cell Based Antagonist cAMP SAFETYscan SafetyScreen Assay - US
Item
87-1002-2342AN
Protein
mu (MOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
alpha1A Human Adrenoceptor GPCR Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2406AG
Protein
alpha1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
alpha1A Human Adrenoceptor GPCR Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2406AN
Protein
alpha1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
A2A Human Adenosine GPCR Cell Based Agonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2409AG
Protein
A2A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
A2A Human Adenosine GPCR Cell Based Antagonist Calcium Flux SAFETYscan SafetyScreen Assay - US
Item
87-1002-2409AN
Protein
A2A
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
AR Human Androgen NHR Cell Based Agonist Nuclear Translocation SAFETYscan SafetyScreen Assay - US
Item
87-1002-2445AG
Protein
AR
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
AR Human Androgen NHR Cell Based Antagonist Nuclear Translocation SAFETYscan SafetyScreen Assay - US
Item
87-1002-2445AN
Protein
AR
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
GR Human Glucocorticoid NHR Cell Based Agonist Protein-Protein Interaction SAFETYscan SafetyScreen Assay - US
Item
87-1002-2454AG
Protein
GR
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
GR Human Glucocorticoid NHR Cell Based Antagonist Protein-Protein Interaction SAFETYscan SafetyScreen Assay - US
Item
87-1002-2454AN
Protein
GR
Organism
Human
Assay Sub Type
Cell Based
Organism:
Human
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Testing Information
Test Sample Requirements:
150uL of a 1000X stock based on the top or final concentration being tested
Turnaround Time
Standard:
20 Business Days
Service Scheduling Note:
Eurofins DiscoverX will make reasonable efforts to deliver screening data within twenty (20) business days from the start date of the scheduled panel provided that Materials and required documentation are received prior to run date. An expedited turnaround time of fifteen (15) business days is available, please inquire with StudyDirectorsServicesSanDiego@discovery.eurofinsus.com
Additional Information
Brand:
SafetyScreen
Testing Location:
USA - San Diego, CA
Questions? Contact Us
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