SERT Human Serotonin Transporter Functional Antagonist Uptake LeadHunter Assay - FR

Background Information:

Na+/Cl--dependent neurotransporters, which constitute a gene superfamily, are crucial for limiting neurotransmitter activity. The action of serotonin is terminated, in part, through its uptake into presynaptic serotonergic neurons by the plasma-membrane serotonin transporter (SERT). The monoamine transporters, such as SERT, are high affinity targets for psychostimulants and antidepressants. These agents, by blocking transporters and consequently preventing neuronal uptake, elevate levels of extracellular neurotransmitter concentrations in both the central and peripheral nervous system, contributing to their behavioral and autonomic effects.

Family:

Transporter

Sub Family:

SLC6 / Monoamine

Class:

SLC

Protein Name:

SERT

Uniprot Number:

P31645

Protein Aliases:

serotonin transporter 1

Gene Name:

SLC6A4

Gene ID:

6532

Gene Aliases:

5-HTT|SERT1|HTT

Accession Number:

NM_001045

Organism:

Human

Cell Type:

CHO