OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
The actions of several neurotransmitters, including serotonin, are regulated through their rapid uptake and clearance from synaptic junctions by plasma membrane transport proteins. The serotonin transporter in central serotoninergic neurons is responsible for the recovery of up to 90 percent of released transmitter. The monoamine transporters are high affinity targets for a number of psychoactive agents such as cocaine, amphetamine, and antidepressants. These agents, by blocking transporters and consequently preventing neuronal uptake, elevate levels of extracellular neurotransmitter concentration in both the central and peripheral nervous systems, contributing to their behavioral and autonomic effects.
Family:
Transporter
Sub Family:
SLC6 / Monoamine
Class:
SLC
Protein Name:
SERT
Uniprot Number:
P31645
Protein Aliases:
serotonin transporter 1
Gene Name:
SLC6A4
Gene ID:
6532
Gene Aliases:
5-HTT|SERT1|HTT
Organism:
Human
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Antagonist
Testing Information
Test Sample Requirements:
300uL of a 1000X stock based on the top or final concentration being tested
Turnaround Time
Standard:
20 Business Days
Service Scheduling Note:
Eurofins DiscoverX will make reasonable efforts to deliver screening data within (20) business days from the start date of the scheduled assay service provided that Materials and required documentation are received prior to run date.
Additional Information
Brand:
SafetyScreen
Testing Location:
USA - San Diego, CA
Questions? Contact Us
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