sst2 Human Somatostatin GPCR Cell Based Antagonist cAMP LeadHunter Assay - US

Background Information:

Somatostatin (somatotropin-release inhibiting factor, SRIF) receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The five known receptors can be divided into two groups: SRIF1 (SRIF1A=sst2, SRIF1B=sst5, srif1C=sst3) and SRIF2 (SRIF2A=sst1, srif2B=sst4); lower case (srif) indicates an as yet undefined physiological role. SRIF receptors are found in most peripheral tissues and within the central nervous system. Agonism at SRIF1A=sst2 receptors may inhibit release of growth hormone (GH), glucagon and acid secretion as well as tumor cell proliferation.

cAMP Hunter™ Gi cell lines overexpress naturally Gi coupled, wild type GPCRs and are designed to detect inhibition of intracellular cAMP production in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Somatostatin

Class:

Class A

Coupling:

Gi/Go

Protein Name:

sst2

Uniprot Number:

P30874

Protein Aliases:

SS2-R|SS2R|SRIF-1

Gene Name:

SSTR2

Gene ID:

6752

Accession Number:

AY236542

Organism:

Human

Cell Type:

CHO-K1