OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Quickly profile key compound in vitro properties essential for selecting candidates with desirable pharmacokinetic (PK) profiles in later stages of drug development with our Tier 1 ADME Panel. The Eurofins Tier 1 ADME panel consists of 8 ADME assays used to determine compound solubility, permeability, protein binding, intrinsic clearance, and lipophilicity, typically run in early drug discovery to prioritize and select compounds with desirable PK properties needed to progress compounds further into development.
No. of Assays on Panel:
8
Assays on Panel:
Family
Name
Aqueous solubility (simulated gastric fluid) - US
Item
2061
Protein
Organism
Assay Sub Type
Family
Name
Aqueous solubility (simulated intestinal fluid) - US
Item
2062
Protein
Organism
Assay Sub Type
Family
Name
Protein binding (plasma, human) - US
Item
2194
Protein
Organism
Human
Assay Sub Type
Family
Name
A-B permeability (Caco-2, pH 6.5/7.4) - US
Item
3318
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
Name
B-A permeability (Caco-2, pH 6.5/7.4) - US
Item
3320
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
Name
Partition coefficient (log D, n-octanol/PBS, pH 7.4) - US
Item
417
Protein
Organism
Assay Sub Type
Family
Name
Aqueous solubility (PBS, pH 7.4) - US
Item
435
Protein
Organism
Assay Sub Type
Family
Name
Intrinsic clearance (liver microsomes- human) - US
Item
607
Protein
Organism
Human
Assay Sub Type
Enzymatic
Testing Information
Test Sample Requirements:
Minimum for 1) Screen: 200 uL of 10 mM DMSO or 2-3 mg of material.
Turnaround Time
Standard:
10 Business Days
Additional Information
Testing Location:
USA - St Charles, MO
Other Information:
Tier 1 ADME Panel Testing Concentrations for Individual Assays; 1) Aqueous solubility assays, ITEM# 2061, 2062, and 435, tested at 1 conc. of 200 uM and 2 replicates, 2) Protein binding assay, ITEM# 2194, tested at 1 conc. of 10 uM and 2 replicates, 3) Caco-2 Permeability assays, ITEM# 3318 and 3320, tested at 1 conc. of 10 uM and 2 replicates, 4) Intrinsic Clearance assay, ITEM# 607, tested at 1 conc. of 0.1 uM and 2 replicates, and 5) Partition Coefficient assay, ITEM# 417, tested at 1 conc. of 100 uM and 3 replicates
Questions? Contact Us
You can easily get in touch with a Eurofins Discovery Expert or get help from our Customer Service team. Reach out with questions, or to discuss your specific discovery challenges.
