TNS4 Human SH2 Domain-Containing SH2scan ELECT Binding LeadHunter Assay - US

Background Information:

Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration. (https://www.uniprot.org/uniprotkb/Q8IZW8/entry). SH2-domain binding assays were developed using Eurofins Discovery's proprietary KINOMEscan technology that utilizes DNA-tagged target proteins and a high sensitivity qPCR readout to enable highly sensitive (accurate ligand KDs measured down to low picomolar range) and quantitative competition binding assays.

Family:

Cytosolic (Other)

Sub Family:

Adhesion

Class:

Tensin

Protein Name:

TENS4

Uniprot Number:

Q8IZW8

Protein Aliases:

C terminal tensin like

Gene Name:

TNS4

Gene ID:

84951

Gene Aliases:

CTEN

Accession Number:

NP_116254.4

Organism:

Human

Construct Details:

Wild Type; Partial Length (Start/Stop:D444/E558); Mammalian Expression