TRPV1 Human Transient Potential Ion Channel Cell Based Antagonist Assay - Qube APC (1 Conc.)

Background Information:

 TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a Protein Coding gene. Diseases associated with TRPV1 include Pulpitis and Somatoform Disorder. Among its related pathways are Trk receptor signaling mediated by the MAPK pathway and Ion channel transport. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and ion channel activity. An important paralog of this gene is TRPV4. Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. TRPV1_HUMAN,Q8NER1

Family:

Ion Channel

Sub Family:

Potassium

Class:

Voltage-Gated

Organism:

Human

Cell Type:

CHO-K1