RESOURCES

Find out how scientists around the world use OncoPanel^™ and BioMAP^® Platforms to improve their potential for clinical success in the fight against cancer.

hERG block potency is widely used to calculate a drug’s safety margin against its torsadogenic potential.

Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems.

Assessing the Regulation of Mast Cell Function and Implications in Safety Pharmacology

The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative is an effort to improve the accuracy of proarrhythmic risk assessment by reducing the focus on in vitro hERG channel assays and in vivo QT interval measurements.

Many drugs are sensitive to light, resulting in the deterioration of their formulated products.

In vitro toxicity testing in translational models such as the BioMAP^® Platform, together with high-throughput ion channel screening, provides a comprehensive assessment.

HTS Cell-Based Functional Assays

Natural products, food ingredients, and cosmetics preservatives are aimed at improving our quality of life.

The PIM serine/threonine kinases (PIM1/PIM2/PIM3) are downstream effectors of ABL, JAK2 and Flt-3 oncogenes and are required for tumorigenesis.

COMT inhibitors are used clinically in the treatment of Parkinson’s disease, and may also be beneficial for people suffering fromother conditions such as schizophrenia⁽¹⁾.

A Case Study on the Design of an Efficient HTS Cascade Focused on the PIM3 Kinase.