Ion Channel Binding Assays

Radioligand displacement assays can be used to achieve your important yes/no interaction determinations, as well as calculating a compound’s affinity for a specific channel of interest. Along with functional assays, binding studies can provide an orthogonal approach to creating a complete profile of your compound’s in vitro pharmacology.
 
Our experts at Eurofins Discovery have developed technology valuable in this area. In addition to our growing portfolio of functional ion channel assays, we offer radioligand binding assays across a number of ion channel families, including: Sodium, potassium, and calcium.
 
We use the gold standard in radioligand binding assays to produce highest assay robustness. Our ion channel binding assays are conducted with membrane preparations produced in-house to control for the quality of these critical reagents and to ensure tight data reproducibility. Radioligand binding assays are a useful approach for monitoring potential hERG liability at the earliest phase of drug discovery where the primary aims are to raise flags that could trigger follow-up studies, such as electrophysiological screening.