Therapeutic compounds can exert widespread and varied effects at the cellular level. As any cell is a balancing act of various functions and processes, subtle or not-so-subtle changes in any of these can have huge consequences. From activation and blockade of cell-signaling pathways beginning at the receptor level and proceeding to downstream effects on proliferation, cell cycle progression, apoptosis, and gene expression, having multiple ways to assess your molecule’s effects at the cellular level leads to better characterizations.
Investigate your MOA and functional characterization with Eurofins Discovery’s cell-based assay assessments for your biotherapeutics:
| Functional Characterization | Description |
|---|---|
| Receptor Activations or Suppressions | Custom assay development for identifying receptor activations or suppressions |
| Signaling Pathway Activations or Suppressions | Assess cellular effects through assessments or suppressions of key cell signaling pathways |
| Changes in Gene Expressions | Assess gene expression changes at the transcriptome level in response to your compounds |
| Changes in Protein Expressions | Assess proteomic changes associated with your compounds |
| Changes in Secretomes | Assess how your compounds affect secreted cytokines, chemokines, and growth factors |
| Changes in Receptor Expressions | Assess how receptor expressions and numbers change in response to your compounds |
| Changes in Cellular Functioning | Assess how your compounds alter key cellular functions |
| Gene Silencing or Knockdowns | Assess the roles of genes-of-interest using gene silencing or knockdown techniques |
| Assessments of mRNA/mIR Therapeutics | Monitor and qualify the effects of your RNA therapeutic using customized approaches |
