DiscoverX provides the largest portfolio of GPCR assays and now for the first time, a unique service that utilizes state of the art tools developed by Professor Terry Kenakin* for characterization of ligand bias. With the appropriate β-Arrestin, Internalization, and 2nd messenger assays to quantify selective response and statistical tools to scale these effects, harnessing bias to produce selective ligands is now made simple.
Service Details
Service: Compound profiling for second messenger, β-arrestin, or internalization assays from a choice of >150 GPCRs. Application of ligand bias analysis to identify statistically significant biased interactions.
Deliverables: Study report containing detailed profile of compounds in two or more signaling pathways. Analysis of activity relative to natural ligands to derive a biased index value.
