Hit finding, or hit identification (Hit ID), can be very challenging – especially in distinguishing between confirmed on-target binding and/or activity and off-target binding. Identifying biologically and pharmacologically active compound series with desired potency and selectivity in early phases of drug discovery requires a team with expertise across multiple disciplines. Eurofins Discovery chemists and biologists can help you design rapid and successful screening programs to deliver validated high-quality hits.
From Activity-based & Affinity-based High Throughput Screening (including High-throughput Spectral Shift (HT-SpS)), to AI-driven drug design, and Fragment-Based Screening (FBS), Eurofins Discovery has a wide variety of solutions for Hit Finding programs. Our experts have access to extensive tools and services, including compound libraries, off-the-shelf in vitro pharmacology assays, automation, biophysics, bioinformatics, chemistry, ADME, safety pharmacology, translational biology, and advanced analysis & prediction solutions, such as Genedata Screener® or SAFIRE. Work with our experienced discovery specialists and project management team to select the right method for your drug discovery challenges.
Time is of the essence? Need an innovative approach? We can support you with a comprehensive range of fully validated, best-in-class services and Eurofins DiscoverX® products. Explore our off-the-shelf assays as well as our customizable services, and quickly identify promising molecules with high potential to go all the way to IND.
Benefits of Choosing Us for Your Discovery Program
Eurofins Discovery’s operational, technical, and project management excellence provides you flexibility to select the most appropriate approach for your needs, from stand-alone assays to tiered HTS or FBS cascades and fully integrated discovery with our Integrated Drug Discovery team.
Our contract research expertise and depth of knowledge in preclinical development mean clients trust us — with new chemical entity development, testing for biological function and early ADME & safety, plus guidance on creating more druggable, tractable hits from the earliest stages of discovery.
Eurofins Discovery Libraries provide access to extensive tractable hit-like property resources, offering you freedom to operate on selected hits:
500,000+ PlatinumDiv+ Library
- High chemical diversity space driven by AI/ comp chem guided library design
- HTS hits with superior lead-like properties (low molecule weight, good predicted solubility & permeability, including BBB)
- Predefined subsets (new chemical spaces, CNS-focus, etc.) with less than 2.7% overlap allowing you the flexibility to scale to your project’s needs (50-500K).
- High quality starting points for H2L programs
1500+ MKAppoved Library
- Prestwick Library of FDA & EMA approved drugs
- Annotated library for targets & therapeutic indications
220,000+ GPCRGenius Library
- Designed library for GPCR targets
- Annotated for GPCR families & classes
2,000+ Fragment ProbeSet
- Novel potential starting points, available for immediate screening
- High 3D shape, non-planar character, covering novel chemical space
We offer all standard & advanced technologies for biochemical, cellular & biophysical screenings, from 384w to 1536w format, including:
- Fluorescence: FI, FP, FRET, TR-FRET, FLIPR (including Tl+), High Content Imaging
- Luminescence: DiscoverX® EFC, InCell Hunter, InCell Pulse, reporter gene assays, bioluminescence assays, etc.
- Mass Spectrometry: Echo® MS, Rapid Fire-MS, QqQ & Q-TOF
- Biophysics: HT-SpS, SPR, MST-TRIC, TSA, up to 1536w format!
- Radioligand binding, qPCR, QUBE384, etc.
Eurofins Discovery DiscoveryAI team support you for successful Virtual Screening, you can combine with any HTS approach to save time and expand scaffold diversity:
- Combined ligand-based and structure-based virtual screening approach
- 27 billion+ compounds virtual chemical libraries
- Patent searching on 100’s of millions of compounds & 10’s millions of compounds from customer ideas
Comprehensive screening cascade adapt to each customer projects, based on single or combined approaches:
- High Throughput Screening
- Activity-based Screening
- Affinity-based Screening
- Virtual Screening
- Fragment-based Screening
- DEL Screening
- Site-agnostic or active-site binder strategies
- Literature-to-Lead
Key Areas Featuring Tools for Designing Successful Fully Tailored Screening
With 10,000+ ready-to-use off-the-shelf assays covering all target classes, cell lines, and reagents, in addition to our extensive screening capabilities, explore Eurofins Discovery’s wide variety of services, designed to ensure the success of your Hit Finding programs.
