In Vivo Pharmacology Models

Generate High-Quality Efficacy and PK Data with Flexible Study Design and Responsive Drug Development Experts

Eurofins Discovery works with partner lab Pharmacology Discovery Services (PDS) in achieving scientific leadership in the creation and optimization of in vivo efficacy models and pharmacokinetic (PK) analysis and testing of small molecules and biotherapeutics – all geared to accommodate your unique study designs and new disease models.
 
Choosing the right in vivo model and study design to measure efficacy is key to translating a preclinical candidate into a treatment that can change patients’ lives. But many testing facilities may only accommodate standard study protocols, disease models, or large study sizes which can slow down your drug development.
 
At Eurofins Discovery, we have built our industry-leading reputation as a CRO by ensuring that our technical experts, project leads, and study directors are responsive to your needs, concerns, and questions. Our team delivers high-quality data that are repeatable, within your required time frame.
 
MODEL FLEXIBILITY: We specialize in multiple active therapeutic areas and can adapt or develop custom models to fit your testing requirements, with focus on: oncology, pain, CNS, autoimmune, inflammation, and antimicrobials (including government-supported research into combatting deadly drug-resistant “superbugs”).
 
Our scientific leadership and commitment to ethical standards show in the support gained from regulators on an international scale when PDS opened its new AAALAC-accredited purpose-built vivarium. We continue to ensure our skilled and experienced staff demonstrates the high value we place on animal welfare. The vivarium, opened in 2018, fulfills the international standards for humane treatment of animals from leading oversight authorities that include the U.S. FDA, the European EMEA and Japan’s MHW.

Key Areas

Comprehensive in vitro and in vivo antimicrobial services. Our collection has 700+ strains, many from the CDC and FDA AR Isolate Bank.

Models for efficacy testing and side-effect profiling. Models include: Acute, Inflammatory, Neuropathic, and Translational pain.

Models to assess gastric acidity, irritation, and molity. Renal function and renal failure models.

Dozens of validated disease models: Arthritis, Dermatitis, Diabetes, Fibrosis, IBD, Lupus, NASH, Pruritus and Psoriasis.

Diabetes (Type I and II), NASH, obesity, and pancreatitis models. Various CV models including hypertension and thrombosis.

Syngeneic murine or human tumor xenograft models that include subcutaneous, orthotopic, or disseminated disease models.

PK and BBB studies to help species selection and design of preclinical toxicology studies.

Qualified safety-related models for early safety and toxicity assessment in various therapeutic areas.

Features