Signal Transducer and Activator of Transcription (STAT) Src Homology 2 (SH2) Domain Binding Assays

Eurofins Discovery has developed a panel of novel LeadHunter^™ assays targeting Signal Transducer and Activation of Transcription (STAT) proteins that play a central role in cytokine, growth factor and oncogenic tyrosine kinase signaling with dysregulation leading to chronic inflammation, auto-immunity and cancer.
 
These novel STAT-specific LeadHunter assays offer unique competition Src Homology 2 (SH2) domain binding assays for 10 STAT family proteins. The STAT SH2 assay panel consists of 7 wild-type and 3 mutant DNA-tagged protein targets. These assays measure selective binding of small molecule inhibitors or degraders to STAT SH2 domains thus enabling novel therapeutic discoveries for cancer and inflammation.
 
For further information, please contact StudyDirectorsServicesSanDiego@discovery.eurofinsus.com
 

Figure 1. Image from the RCSB PDB (rcsb.org) of PDB ID 1BG1 (Stefan Becker, Bernd Groner & Christoph W. Müller) (1998) Three-Dimensional Structure of the Stat3B homodimer bound to DNA Nature 394,145-151) https://doi.org/10.1038/28101