M1 Human Acetylcholine (Muscarinic) GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR

Background Information:

Muscarinic receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Muscarinic receptors are widely distributed in the central and peripheral nervous system as well as various tissues.

Family:

GPCR

Sub Family:

Acetylcholine (Muscarinic)

Class:

Class A

Protein Name:

M1

Uniprot Number:

P11229

Protein Aliases:

acetylcholine receptor, muscarinic 1

Gene Name:

CHRM1

Gene ID:

1128

Accession Number:

NM_000738

Organism:

Human

Construct Details:

Recombinant

Cell Type:

CHO-K1