P-gp Human Transporter Cell Based Antagonist (calcein AM substrate) Assay - US

Background Information:

Transporters are membrane proteins that control the influx and efflux of essential nutrients, ions, cellular waste, environmental toxins, and other xenobiotics such as drugs. Transporters that transport drugs across the membrane are from two major superfamilies, ABC (ATP binding cassette) and SLC (solute carrier) transporters. Eurofins has a variety of robust transporter inhibition assays to allow quick and cost-effective screening of new molecular entities (NMEs) for their interactions with these transporters. Results from these assays are important in assessing a drug’s efficacy, safety, and pharmacokinetic properties, and are also necessary for compliance with FDA and EMA guidances.

Family:

Transporter

Sub Family:

ABCB

Class:

ABC

Protein Name:

P-gp

Uniprot Number:

P08183

Protein Aliases:

multidrug resistance protein 1

Gene Name:

ABCB1

Gene ID:

5243

Gene Aliases:

P-gp|CD243|GP170|ABC20

Organism:

Human

Construct Details:

Full length, recombi

Cell Type:

MDCKII