B-A permeability (MDR1-MDCKII, pH 7.4/7.4) - US

Background Information:

The absorption of orally administered drugs requires the movement of the drug across the intestinal epithelial barrier. Intestinal permeability is a critical characteristic that determines the rate and extent of in vivo absorption and is correlated with the bioavailability of a drug candidate. MDR1-MDCKII cells are Madin-Darby canine kidney cells which express the human MDR1 gene and which have been widely used as an in vitro model for drug transport and permeability screening of discovery compounds.

Family:

Transporter

Sub Family:

ABCB

Class:

ABC

Protein Name:

P-gp

Uniprot Number:

P08183

Protein Aliases:

multidrug resistance protein 1

Gene Name:

ABCB1

Gene ID:

5243

Gene Aliases:

P-gp|CD243|GP170|ABC20

Organism:

Human

Construct Details:

Full Length, Recombi

Cell Type:

MDCKII