Biological Information

Family:

GPCR

Sub Family:

Glucagon

Class:

Class B

Protein Name:

GLP-1

Uniprot Number:

P43220

Protein Aliases:

GLP-1-R|GLP-1R

Gene Name:

GLP1R

Gene ID:

2740

Accession Number:

NM_002062

Organism:

Mouse

Assay Information

Assay Type:

Biochemical

Assay Sub Type:

Binding

Detection Method:

Radiometric

Measured Response:

Scintillation

Testing Information

Ligand:

[125I]GLP-1(7-36)

Ligand Kd (nM):

0.1

Ligand Concentration:

0.025 nM

Non Specific:

1 µM GLP-1(7-36)

Incubation:

120 min at 37°C

Control Inhibitor:

Exendin 4

Test Concentration / Dose:

Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.

Test Sample Requirements:

Minimum for 1) Screen: 60 µl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing. 2) Dose Response: 90 µl of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.

Minimum Order Quantity:

2

Turnaround Time

Standard:

15 Business Days

Reference Compound Data

PubChem ID

56927919

Name

Exendin 4

Measurement

0.19nM - IC50

PubChem ID

Name

exendin-3(9-39)

Measurement

1.9nM - IC50

PubChem ID

Name

GLP-1(7-36)

Measurement

0.25nM - IC50

PubChem ID

Name

glucagon amide

Measurement

- IC50

Clinical Relevance

Therapeutic Area:

Metabolic Diseases

Additional Information

Brand:

LeadHunter

Testing Location:

France - Celle L'Evescault

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Item: 2182
Item: G072