5-HT2B Human Serotonin GPCR Binding Antagonist Radioligand LeadHunter Assay - TW

Background Information:

Serotonin 5-HT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins with the exception of the 5-HT3 subtype, which belongs to the ligand gated cation superfamily of receptors. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Serotonin 5-HT2 receptors are widely distributed in the central nervous system and peripheral tissues. The 5-HT2 receptor class couples preferentially to Gq/G11 to increase hydrolysis of inositol phosphates and to elevate cytosolic [Ca2+]. Serotonin 5-HT2B receptor agonism may promote pulmonary and peripheral hypertension, but most importantly has been linked to serious cardiac valvulopathy. Receptor antagonism may be useful for the treatment of migraine headache.

Family:

GPCR

Sub Family:

Serotonin

Class:

Class A

Protein Name:

5-HT2B

Uniprot Number:

P41595

Protein Aliases:

5-HT2B|Serotonin receptor 2B

Gene Name:

HTR2B

Gene ID:

3357

Gene Aliases:

5-HT(2B)|5-HT2B

Accession Number:

NM_000867

Organism:

Human

Construct Details:

Full Length, Recombinant