alpha1A Human Adrenoceptor GPCR Cell Based Agonist IP1 LeadHunter Assay - TW
OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Adrenoreceptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Adrenoreceptors are found in most peripheral tissue and within the central nervous system.
Family:
GPCR
Sub Family:
Adrenoceptor
Class:
Class A
Protein Name:
alpha1A
Uniprot Number:
P35348
Protein Aliases:
Alpha-1A adrenoceptor|Alpha-1C adrenergic receptor|Alpha-adrenergic receptor 1c
Gene Name:
ADRA1A
Gene ID:
148
Gene Aliases:
ADRA1L1|ADRA1C
Accession Number:
NM_033303
Organism:
Human
Construct Details:
Full Length, Recombinant
Cell Type:
CHO-K1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist
Detection Method:
TR-FRET
Measured Response:
Fluorescence
Testing Information
Incubation:
30 min at 37°C
Control Activator:
CHEMBL109783
Criteria For Significance:
≥ 50% increase in IP-one relative to A61603 response, ≥ 50% Inhibition of A61603-induced response
Test Concentration / Dose:
Compounds are screened at 10, 3, 1, 0.3, 0.1, 0.03, 0.01 and 0.003 μM
Test Sample Requirements:
75 μl of 10 mM stock or 1 mg (pre-weighed) powder (assuming FW ≦500 and purity 100%)
Minimum Order Quantity:
16
Turnaround Time
Standard:
20 Business Days
Reference Compound Data
Clinical Relevance
Therapeutic Area:
Cardiovascular
Adverse / Beneficial Action:
Adrenergic a1A receptor antagonism may result in hypotension as well as orthostatic hypotension and may be useful in the treatment of benign prostatic hyperplasia.
Additional Information
Brand:
LeadHunter
Testing Location:
Taiwan - Taipei
RELATED SOLUTIONS
alpha1A Human Adrenoceptor GPCR Cell Based Agonist & Antagonist IP1 LeadHunter Assay - TW
Item: 302040
alpha1A Human Adrenoceptor GPCR Cell Based Antagonist IP1 LeadHunter Assay - TW
Item: 302040-1
alpha1A Rat Adrenoceptor GPCR Binding (Antagonist Radioligand) Assay, Panlabs
Item: 203100
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