OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Evaluation of two compounds in any BioMAP system, individually and in combination. The 4H system is comprised of venular endothelial cells and models Th2 type vascular inflammation. It is a pro-angiogenic environment that promotes mast cell, basophil, eosinophil, T and B cell recruitment. The 4H system is relevant for diseases where Th2-type inflammatory conditions play a role such as allergy, asthma, and ulcerative colitis.
Organism:
Human
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Testing Information
Test Concentration / Dose:
Two test agents profiled alone at four concentrations, and in combination in a four-by-four matrix, in triplicate.
Test Sample Requirements:
For Small Molecules: 350uL of a 1000X stock based on the top concentration being tested & standard 3-fold dilutions per system and per Combo. For Biologics: 3.5mL of a 100X stock in PBS or water, based on the top concentration being tested & standard 3-fold dilutions per system and per Combo
Turnaround Time
Standard:
40 Business Days
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
BioMAP
Testing Location:
USA - St Charles, MO
RELATED SOLUTIONS
BioMAP Diversity PLUS
Item: 89-0001-0903
BioMAP Systems ELECT Menu 1 (4H)
Item: 89-0003-0002
BioMAP Combo ELECT Menu 2 (BF4T)
Item: 89-0015-0006
BioMAP Combo ELECT Menu 1 (HNo)
Item: 89-0015-0028
BioMAP RNA ELECT (4H)
Item: 89-0035-0002
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