CB2 Human Cannabinoid GPCR Cell Based Agonist & Antagonist cAMP LeadHunter Assay - FR
OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Cannabinoid receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Cannabinoid CB2 receptors are found primarily in immune tissues.
No. of Assays on Panel:
2
Assays on Panel:
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1746
Protein
CB2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1747
Protein
CB2
Organism
Human
Assay Sub Type
Cell Based
Family:
GPCR
Sub Family:
Cannabinoid
Class:
Class A
Protein Name:
CB2
Uniprot Number:
P34972
Protein Aliases:
CB2|hCB2|CX5
Gene Name:
CNR2
Gene ID:
1269
Gene Aliases:
CB2
Organism:
Human
Cell Type:
CHO-K1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist & Antagonist
Detection Method:
HTRF
Testing Information
Incubation:
10 min at 37°C
Control Activator:
WIN 55212-2 (3 nM)
Test Concentration / Dose:
Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.
Test Sample Requirements:
Minimum for 1) Screen: 60 µL of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM finµL testing. 2) Dose Response: 90 µL of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
16
Turnaround Time
Standard:
15 Business Days
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Adverse / Beneficial Action:
Cannabinoid CB2 receptor agonism may limit angiogenesis as well as induce apoptosis in some types of cancer, inhibit inflammatory pain and the immune system. CB2 receptor antagonism may facilitate mast cell-mediated allergic and inflammatory responses.
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
CB2 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item: 37
CB2 Human Cannabinoid GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item: 1746
CB2 Human Cannabinoid GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item: 1747
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