DAT Human Dopamine Transporter Binding Antagonist Radioligand LeadHunter Assay - FR

Background Information:

The actions of several neurotransmitters, including dopamine, are regulated through their rapid uptake and clearance from synaptic junctions by plasma membrane transport proteins. The dopamine transporter in central dopaminergic neurones is responsible for the recovery of up to 90% of released transmitter. The monoamine transporters are high affinity targets for a number of psychoactive agents such as cocaine, amphetamine, and antidepressants. These agents, by blocking transporters and consequently preventing neuronal uptake, elevate levels of extracellular neurotransmitter concentrations in both the central and peripheral nervous system, contributing to their behavioral and autonomic effects.

Family:

Transporter

Sub Family:

SLC6 / Monoamine

Class:

SLC

Protein Name:

DAT

Uniprot Number:

Q01959

Protein Aliases:

dopamine transporter

Gene Name:

SLC6A3

Gene ID:

6531

Gene Aliases:

DAT|DAT1

Accession Number:

NM_001044

Organism:

Human

Construct Details:

Recombinant