ETA Human Endothelin GPCR Cell Based Agonist & Antagonist Calcium Flux LeadHunter Assay - FR

Background Information:

Endothelin receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Endothelin receptors are widely expressed in all tissues, ETA receptors primarily on vascular smooth muscles and ETB receptors primarily on endothelial cells. Receptors are also localized to non-vascular structures such as epithelial cells and in central nervous system glia and neurones.

No. of Assays on Panel:

2

Family:

GPCR

Sub Family:

Endothelin

Class:

Class A

Protein Name:

ETA

Uniprot Number:

P25101

Protein Aliases:

ET-A|ET-AR

Gene Name:

EDNRA

Gene ID:

1909

Organism:

Human

Cell Type:

SK-N-MC