A3 Human Adenosine GPCR Cell Based Agonist & Antagonist cAMP LeadHunter Assay - FR
OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Adenosine receptors belong to the superfamily of G-protein coupled receptors and contain 7 transmembrane domains. Four major subtypes of the adenosine receptor have been termed A1, A2A, A2B and A3. A3 receptors are found in high levels in the testis, and in lower levels in the lung, kidney, heart, and CNS.
No. of Assays on Panel:
2
Assays on Panel:
Family
GPCR
Name
A3 Human Adenosine GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
982
Protein
A3
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
A3 Human Adenosine GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
983
Protein
A3
Organism
Human
Assay Sub Type
Cell Based
Family:
GPCR
Sub Family:
Adenosine
Class:
Class A
Protein Name:
A3
Uniprot Number:
P0DMS8
Gene Name:
ADORA3
Gene ID:
140
Gene Aliases:
AD026
Organism:
Human
Cell Type:
CHO-K1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist & Antagonist
Detection Method:
HTRF
Testing Information
Incubation:
20 min at 37°C
Control Activator:
IB-MECA (10 nM)
Test Concentration / Dose:
Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.
Test Sample Requirements:
Minimum for 1) Screen: 60 µL of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM finµL testing. 2) Dose Response: 90 µL of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
16
Turnaround Time
Standard:
15 Business Days
Clinical Relevance
Therapeutic Area:
CNS/Addiction/Pain
Adverse / Beneficial Action:
Adenosine A3 receptor agonism may activate neutrophils, eosinophils and macrophages to produce cytokines useful in the treatment of inflammation, brain/cardiac ischemia and cancer, but may enhance mediator release from basophils and mast cells to augment asthma and other allergic conditions.
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
A3 Human Adenosine GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item: 6
A3 Human Adenosine GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item: 982
A3 Human Adenosine GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item: 983
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