A3 Human Adenosine GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Adenosine receptors belong to the superfamily of G-protein coupled receptors and contain 7 transmembrane domains. Four major subtypes of the adenosine receptor have been termed A1, A2A, A2B and A3. A3 receptors are found in high levels in the testis, and in lower levels in the lung, kidney, heart, and CNS.
Family:
GPCR
Sub Family:
Adenosine
Class:
Class A
Protein Name:
A3
Uniprot Number:
P0DMS8
Gene Name:
ADORA3
Gene ID:
140
Gene Aliases:
AD026
Accession Number:
NM_000677|NM_020683
Organism:
Human
Construct Details:
Recombinant
Cell Type:
CHO-K1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist
Detection Method:
HTRF
Testing Information
Incubation:
20 min at 37°C
Control Activator:
IB-MECA
Test Concentration / Dose:
Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.
Test Sample Requirements:
Minimum for 1) Screen: 60 µL of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM finµL testing. 2) Dose Response: 90 µL of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
16
Turnaround Time
Standard:
15 Business Days
Reference Compound Data
Clinical Relevance
Therapeutic Area:
CNS/Addiction/Pain
Adverse / Beneficial Action:
Adenosine A3 receptor agonism may activate neutrophils, eosinophils and macrophages to produce cytokines useful in the treatment of inflammation, brain/cardiac ischemia and cancer, but may enhance mediator release from basophils and mast cells to augment asthma and other allergic conditions.
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
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