OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Why choose The SafetyScreen33 Delta:
The SafetyScreen33 Delta binding Panel expands established safety profiling from 2012 recommendations (Bowes et al. Nat Rev Drug Discov , 2012) by assessing 33 emerging safety-relevant targets in addition to the well-adopted targets covered in the SafetyScreen44 and SafetyScan47 panels, earlier detection of off-target safety liabilities and improved safety-margin assessment.
The panel is designed to reach the 77-target safety coverage considered current industry best practices for early off-target risk assessment, as reflected in meta-analysis of Top 20 pharma worldwide under the IQ DruSafe consortium (Brennan et al., Nat Rev Drug Discov , 2024).
Key Benefits of SafetyScreen33 delta binding:
The combination of SafetyScreen44 or SafetyScan47 and SafetyScreen33 Delta is ICH S7A/B aligned for IND-submission.
Fast start & TAT: profiling begins the day after compound receipt. No scheduling, to meet tight deadline and ensure fast TAT of 10 Business Days.
Visualize and interpret your data with In Vitro Safety Insight : identify organ risks, rank compounds, and access follow-up assay recommendations (available in your online account).
Access data early: results released as they are validated.
Final report delivered electronically with notification.
Cost-effective package.
What’s Next:
Follow-up your hit profile in Binding IC₅₀/EC₅₀ or in Functional IC₅₀/EC₅₀ .
No. of Assays on Panel:
33
Assays on Panel:
Family
GPCR
Name
NK3 Human Tachykinin GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
104
Protein
NK3
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT6 Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
142
Protein
5-HT6
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
RARalpha Human Retinoic Acid NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
2084
Protein
RARalpha
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
PR Human Progesterone NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
2341
Protein
PR
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
Monoamine Oxidase B (MAO-B) Human Enzymatic LeadHunter Assay - FR
Item
3477
Protein
MAO-B
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
CCK2 (CCKB) Human Cholecystokinin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
41
Protein
CCK2 (CCKB)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
MRGX2 (MRGPRX2) Human Class A Orphan GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
4282
Protein
MRGX2 (MRGPRX2)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
D3 Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
48
Protein
D3
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
ERalpha Human Estrogen NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
5484
Protein
ERalpha
Organism
Human
Assay Sub Type
Binding
Family
Kinase
Name
GSK3beta (GSK3B) Human CMGC Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5610
Protein
GSK3beta
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Src Human TK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5611
Protein
Src
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ROCK2 Human AGC Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5620
Protein
ROCK2
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
IR (INSR) Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5623
Protein
IR
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Aurora-A (AURKA) Human Other Protein Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5628
Protein
Aurora-A
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
EGFR Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5631
Protein
EGFR
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
c-Kit Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5633
Protein
Kit
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
TRKA Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5634
Protein
TRKA
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
FGFR1 Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5635
Protein
FGFR1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ROCK1 Human AGC Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5637
Protein
ROCK1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
KDR (VEGFR2) (KDR) Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5639
Protein
KDR (VEGFR2)
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Flt-1 (VEGFR1) (FLT1) Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5641
Protein
Flt-1 (VEGFR1)
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
GPBA (TGR5) Human Bile acid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
5713
Protein
GPBA receptor
Organism
Human
Assay Sub Type
Binding
Family
Epigenetic
Name
BRD4 (1) Human Bromodomain-Containing 4 Binding LeadHunter Assay - FR
Item
5716
Protein
BRD4
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
MALT1 Human Protease Enzymatic Fluorimetry LeadHunter Assay - FR
Item
5717
Protein
MALT1
Organism
Human
Assay Sub Type
Enzymatic
Family
Transporter
Name
GAT1 Human GABA Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
5773
Protein
GAT-1
Organism
Human
Assay Sub Type
Binding
Family
Kinase
Name
PDHK1 (PDK1) Human Kinase Other protein Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5810
Protein
PDK1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Aurora-B (AURKB) Human Other Protein Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5811
Protein
Aurora-B
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
FAK Human TK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5813
Protein
FAK
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
MKK7 (MAP2K7) Human Kinase STE Enzymatic [Km ATP] SafetyScreen - FR
Item
5814
Protein
MAPKK 7
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ATM Human PIKK Kinase Enzymatic [Km ATP] SafetyScreen - FR
Item
5815
Protein
ATM
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
PI3Kgamma (PIK3CG) (p120gamma) Human PtdIns(4,5)P 3-Kinase Enzymatic [Km ATP] SafetyScreen - FR
Item
5816
Protein
PI3Kgamma
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
CLIK (STK35) Human Other Protein Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5817
Protein
CLIK
Organism
Human
Assay Sub Type
Enzymatic
Family
Enzyme
Name
Cathepsin D Human Pepsin Aspartic Peptidase Enzymatic LeadHunter Assay - FR
Item
650
Protein
Cathepsin D
Organism
Human
Assay Sub Type
Enzymatic
Testing Information
Test Sample Requirements:
Minimum for Screen: 130 μl of 10 mM stock -OR- 1 mg (pre-weighed) for 10 µM final testing.
(PBS or HBSS working solutions are not compatible)
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
SafetyScreen
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
SafetyScreen44 Panel - FR
Item: P270
SafetyScreen77 Core Extended Panel - FR
Item: P456
SafetyScreen77 Functional Core Extended Panel - FR
Item: P460-EU
Questions? Contact Us
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