OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Why choose SafetyScreen44:
Industry gold-standard from 2012 recommendations (Bowes et al. Nat Rev Drug Discov , 2012) for in vitro secondary pharmacology profiling with 44 targets (24 GPCRs, 8 ion channels, 6 enzymes, 1 Kinase, 3 transporters, 2 nuclear receptors) expressed in core battery systems (central nervous, cardiovascular, and respiratory) and secondary organ systems (gastrointestinal and renal). With these off-targets screening recommended by 4 major pharmaceutical companies in 2012, the SafetyScreen44 is ICH S7A/B aligned and already well adopted in IND / CTA -submission.
Key Benefits from running SafetyScreen44, also known as CEREP panel:
Cost-effective package for screening activities and early derisking for compound triage and optimization.
Visualize and interpret your data with In Vitro Safety Insight: identify organ risks, rank compounds, and access follow-up assay recommendations (available in your online account).
Fast start: profiling begins the day after compound receipt. No scheduling, to meet tight deadline and ensure fast TAT.
Access data early: results released as they are validated.
Final report delivered electronically with notification..
Eligible for the French Crédit Impôt Recherche (CIR) tax incentive.
What’s Next after SafetyScreen44:
Follow-up your hits with Binding or Functional IC₅₀/EC₅₀.
Need broader coverage? Reach 77 targets with SafetyScreen33 Delta (P453), to align with current industry best practices (Brennan, R.J., et al. Nat Rev Drug Discov , 2024).
Another option is to enlarge the target coverage of SafetyScreen44 in ion channel and same family GPCR with Delta SafetyScreen87 - SafetyScreen44 Panel (P363).
No. of Assays on Panel:
44
Assays on Panel:
Family
GPCR
Name
delta (DOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
114
Protein
delta (DOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
mu (MOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
118
Protein
mu (MOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
H2 Human Histamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
1208
Protein
H2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha2A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
13
Protein
alpha2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT1A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
131
Protein
5-HT1A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D2S Human Dopamine GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
1322
Protein
D2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2B Human Serotonin GPCR [125I](±)DOI Binding Agonist Radioligand LeadHunter Assay - FR
Item
1333
Protein
5-HT2B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
V1A Human Vasopressin / Oxytocin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
159
Protein
V1A
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
KV (Non-Selective) Rat Potassium Ion Channel [125I] alpha-Dendrotoxin Binding LeadHunter Assay - FR
Item
166
Protein
Kv1.1
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
beta1 Human Adrenoceptor GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
18
Protein
beta1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
beta2 Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
20
Protein
beta2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha1A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
2338
Protein
alpha1A
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
nAChR (alpha4/beta2) Human Ion Channel Binding Agonist Radioligand LeadHunter Assay - FR
Item
3029
Protein
nAChR
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
NET Human Norepinephrine Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
355
Protein
NET
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
Acetylcholinesterase Human Enzymatic LeadHunter Assay - FR
Item
363
Protein
AChE
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
37
Protein
CB2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CCK1 (CCKA) Human Cholecystokinin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
39
Protein
CCK1 (CCKA)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
A2A Human Adenosine GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4
Protein
A2A
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
PDE3A Human Phosphodiesterase Enzymatic LeadHunter Assay - FR
Item
4072
Protein
PDE3A
Organism
Human
Assay Sub Type
Enzymatic
Family
Enzyme
Name
PDE4D2 Human Phosphodiesterase Enzymatic LeadHunter Assay - FR
Item
4077
Protein
PDE4D
Organism
Human
Assay Sub Type
Enzymatic
Family
Ion Channel
Name
hERG Human Potassium Ion Channel [3H] Dofetilide Binding Antagonist Radioligand SafetyScreen - FR
Item
4094
Protein
hERG
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
5-HT3 Human Serotonin Ion Channel Binding Antagonist Radioligand LeadHunter Assay - FR
Item
411
Protein
5-HT3A
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
COX1 Human Cyclooxygenase Enzymatic LeadHunter Assay - FR
Item
4173
Protein
COX1
Organism
Human
Assay Sub Type
Enzymatic
Family
Enzyme
Name
COX2 Human Cyclooxygenase Enzymatic LeadHunter Assay - FR
Item
4186
Protein
COX2
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
5-HT1B Human Serotonin GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
4376
Protein
5-HT1B
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
SERT Human Serotonin Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
439
Protein
SERT
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D1 Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
44
Protein
D1
Organism
Human
Assay Sub Type
Binding
Family
Neurotransmitter Metabolism
Name
Monoamine Oxidase A (MAO-A) Rat Binding Antagonist Radioligand LeadHunter Assay - FR
Item
443
Protein
MAO-A
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
kappa (KOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4461
Protein
kappa (KOP)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (alpha1/beta2/gamma2) Human Ion Channel [3H] Flunitrazepam Binding Agonist Radioligand LeadHunter Assay - FR
Item
4518
Protein
GABAA(BZD site)
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
GR Human Glucocorticoid NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
469
Protein
GR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CB1 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4708
Protein
CB1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
471
Protein
5-HT2A
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
DAT Human Dopamine Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
52
Protein
DAT
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
ETA Human Endothelin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
54
Protein
ETA
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav1.2 (L-type) Human Calcium Ion Channel Binding (Dihydropyridine Site) LeadHunter Assay - FR
Item
5538
Protein
CaV1.2 (DHP site)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Sodium Channel Site2 (Non-selective) Rat Ion Channel Batrachotoxin Mass Spectrometry Binding LeadHunter Assay - FR
Item
5572
Protein
Nav1.5
Organism
Rat
Assay Sub Type
Binding
Family
Kinase
Name
Lck Human TK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5617
Protein
Lck
Organism
Human
Assay Sub Type
Enzymatic
Family
Ion Channel
Name
Glutamate (NMDA, NR1/NR2A) Human Ion Channel [3H] CGP-39653 Binding LeadHunter Assay - FR
Item
5875
Protein
GluN1 / GluN2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
H1 Human Histamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
870
Protein
H1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M1 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
91
Protein
M1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M2 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
93
Protein
M2
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
AR Human Androgen NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
933
Protein
AR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M3 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
95
Protein
M3
Organism
Human
Assay Sub Type
Binding
Testing Information
Test Sample Requirements:
Minimum for Screen: 90 μl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing.
(PBS or HBSS working solutions are not compatible)
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
SafetyScreen
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
Delta SafetyScreen87 - SafetyScreen44 Panel - FR
Item: P363
SafetyScreen33 Delta Panel - FR
Item: P453
Questions? Contact Us
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