Cathepsin D Human Pepsin Aspartic Peptidase Enzymatic LeadHunter Assay - TW

Background Information:

Cathepsin D is a major intracellular member of the mammalian aspartic proteinase family. The enzyme is thought to be in the normal degradation of intracellular and extracellular proteins. It has also been suggested that the enzyme plays a role in the generation of biologically active peptides, the processing of exogenous antigens and the b-amyloid precursor protein in Alzheimer’s disease. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Moreover, recent interest in this enzyme arose from the discovery of its possible role in the execution of cell death and the progression of neoplastic diseases.

Family:

Protease

Sub Family:

Pepsin

Class:

Aspartic Peptidase

Protein Name:

Cathepsin D

Uniprot Number:

P07339

Protein Aliases:

ceroid-lipofuscinosis, neuronal 10

Gene Name:

CTSD

Gene ID:

1509

Gene Aliases:

CLN10

Accession Number:

NM_001909

Organism:

Human

Construct Details:

Endogenous