Cathepsin S Human Papain Cysteine Peptidase Enzymatic LeadHunter Assay - TW

Background Information:

Cathepsin B, H, K, L and S are lysosomal cysteine proteases and participate in a variety of proteolytic processes, including degradation of the extracellular matrix. Cathepsin S (EC 3.4.22.27 ) is highly expressed in lymph nodes, spleen, and antigen-presenting cells, including B lymphocytes, macrophages, and dendritic cells. Cathepsin S mediates degradation of the MHC class II invariant chain Ii and participates in antigen processing. Cathepsin S is also present during both the proliferative and secretory phases of the menstrual cycle. Inhibition of cathepsin S may be useful for immunosuppresive therapy of allergies or autoimmune diseases as well as tumors.

Family:

Protease

Sub Family:

Papain

Class:

Cysteine Peptidase

Protein Name:

Cathepsin S

Uniprot Number:

P25774

Gene Name:

CTSS

Gene ID:

1520

Accession Number:

NM_004079

Organism:

Human

Construct Details:

Full Length, Recombinant