kappa (KOP) Rat Opioid GPCR Cell Based Agonist & Antagonist cAMP LeadHunter Assay - FR

Background Information:

Opiates exert their effects in the central and peripheral nervous systems through interaction with m, k and d, three major types of opioid receptors, which are structural homologues and belong to the G protein-coupled receptor (GPCR) family. G-protein cascades activated by these three receptors can reduce adenylyl cyclase activity, alter inositol trisphosphate turnover, activate G-protein-linked, inward potassium channels, and close calcium channels. These receptors mediate the actions of opiate drugs and endogenous opioid neuropeptides in producing euphoria, modulating pain perception, and altering other important functions in the central and peripheral nervous systems.

No. of Assays on Panel:

2

Family:

GPCR

Sub Family:

Opioid

Class:

Class A

Protein Name:

kappa (KOP)

Uniprot Number:

P41145

Protein Aliases:

KOR-1

Gene Name:

OPRK1

Gene ID:

4986

Gene Aliases:

KOR|OPRK

Organism:

Rat

Cell Type:

CHO-K1