OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Why choose SafetyScreen18:
The SafetyScreen18 binding Panel provides secondary pharmacology profiling across 18 high-priority targets showing high hit rate and strongly associated with clinical adverse effects, enabling very early de-risking of chemical series and rapid identification of critical safety liabilities due to short TAT (10 business days started the next day of compound reception).
The panel design is informed by current industry best practices reflecting meta-analysis of Top 20 pharma worldwide under the IQ DruSafe consortium (Brennan, R.J., et al. Nat Rev Drug Discov , 2024), to support off-target mitigation and more confident decision-making for safer drug candidates.
Key Benefits of SafetyScreen18 binding:
Fast start & TAT: profiling begins the day after compound receipt. No scheduling, to meet tight deadline and ensure fast TAT of 7 Business Days.
Visualize and interpret your data with In Vitro Safety Insight : identify organ risks, rank compounds, and access follow-up assay recommendations (available in your online account).
Access data early: results released as they are validated.
Final report delivered electronically with notification.
Cost-effective package.
What’s Next:
In order to get a complete safety assessment and for IND-submission, SatetyScreen59 needs to be performed in cascade after SafetyScreen18 to reach the 77 latest recommended targets by the industry.
Follow-up your hit profile in Binding IC₅₀/EC₅₀ or in Functional IC₅₀/EC₅₀ .
No. of Assays on Panel:
18
Assays on Panel:
Family
GPCR
Name
mu (MOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
118
Protein
mu (MOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2B Human Serotonin GPCR [125I](±)DOI Binding Agonist Radioligand LeadHunter Assay - FR
Item
1333
Protein
5-HT2B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
beta2 Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
20
Protein
beta2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha1A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
2338
Protein
alpha1A
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
NET Human Norepinephrine Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
355
Protein
NET
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
Acetylcholinesterase Human Enzymatic LeadHunter Assay - FR
Item
363
Protein
AChE
Organism
Human
Assay Sub Type
Enzymatic
Family
Enzyme
Name
PDE3A Human Phosphodiesterase Enzymatic LeadHunter Assay - FR
Item
4072
Protein
PDE3A
Organism
Human
Assay Sub Type
Enzymatic
Family
Enzyme
Name
PDE4D2 Human Phosphodiesterase Enzymatic LeadHunter Assay - FR
Item
4077
Protein
PDE4D
Organism
Human
Assay Sub Type
Enzymatic
Family
Ion Channel
Name
hERG Human Potassium Ion Channel [3H] Dofetilide Binding Antagonist Radioligand SafetyScreen - FR
Item
4094
Protein
hERG
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D1 Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
44
Protein
D1
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (alpha1/beta2/gamma2) Human Ion Channel [3H] Flunitrazepam Binding Agonist Radioligand LeadHunter Assay - FR
Item
4518
Protein
GABAA(BZD site)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Nav1.5 Human Sodium Ion Channel (Batrachotoxin site 2) Mass Spectrometry Binding LeadHunter Assay - FR
Item
4520
Protein
Nav1.5
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CB1 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4708
Protein
CB1
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
DAT Human Dopamine Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
52
Protein
DAT
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav1.2 (L-type) Human Calcium Ion Channel Binding (Dihydropyridine Site) LeadHunter Assay - FR
Item
5538
Protein
CaV1.2 (DHP site)
Organism
Human
Assay Sub Type
Binding
Family
Kinase
Name
Lck Human TK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5617
Protein
Lck
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
H1 Human Histamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
870
Protein
H1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M3 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
95
Protein
M3
Organism
Human
Assay Sub Type
Binding
Testing Information
Test Sample Requirements:
Minimum for Screen: 90 μl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing.
(PBS or HBSS working solutions are not compatible)
Turnaround Time
Standard:
7 Business Days
Additional Information
Brand:
SafetyScreen
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
SafetyScreen59 Extended Panel - FR
Item: P448
SafetyScreen77 Core Extended Panel - FR
Item: P456
SafetyScreen77 Functional Core Extended Panel - FR
Item: P460-EU
SafetyScreen18 Functional Core Panel - FR
Item: P452-EU
Questions? Contact Us
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