OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Safety pharmacology is a science of detecting adverse effect liability, predicting potential risks, and accounting safety margin of medicine. An unexpected off-target hit might cause undesirable adverse effects or lead to discontinuation of drug development. Our SafetyScreen 44 and 87 provide a solution to identify off-target activities, which include the molecular targets (G-protein-coupled receptor, ionic channel, enzyme, transporter, and nuclear receptor) expressing in core battery systems (central nervous, cardiovascular, and respiratory) and secondary organ systems (gastrointestinal and renal), which are related to undesirable adverse effects.
No. of Assays on Panel:
87
Assays on Panel:
Family
Neurotransmitter Metabolism
Name
Acetylcholinesterase Human Enzymatic LeadHunter Assay - TW
Item
104010
Protein
Acetylcholinesterase
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
ACE Human Angiotensin-Converting Metallo Peptidase Enzymatic LeadHunter Assay - TW
Item
107310
Protein
ACE
Organism
Human
Assay Sub Type
Enzymatic
Family
Transporter
Name
ATPase (Na+/K+) Human HeLa S3 Cell Enzymatic LeadHunter Assay – TW
Item
107720
Protein
Na+/K+ ATPase
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
Cathepsin G Human Chymotrypsin Serine Peptidase Enzymatic LeadHunter Assay - TW
Item
112510
Protein
Cathepsin G
Organism
Human
Assay Sub Type
Enzymatic
Family
Lipid Metabolism
Name
COX1 Human Cyclooxygenase Enzymatic LeadHunter Assay - TW
Item
116030
Protein
COX1
Organism
Human
Assay Sub Type
Enzymatic
Family
Lipid Metabolism
Name
COX2 Human Cyclooxygenase Enzymatic LeadHunter Assay - TW
Item
118030
Protein
COX2
Organism
Human
Assay Sub Type
Enzymatic
Family
Oxidoreductase
Name
Monoamine Oxidase A (MAO-A) Human Enzymatic LeadHunter Assay - TW
Item
140010
Protein
MAO-A
Organism
Human
Assay Sub Type
Enzymatic
Family
Oxidoreductase
Name
Monoamine Oxidase B (MAO-B) Human Enzymatic LeadHunter Assay - TW
Item
140120
Protein
MAO-B
Organism
Human
Assay Sub Type
Enzymatic
Family
PDE
Name
PDE3A Human Phosphodiesterase Enzymatic LeadHunter Assay - TW
Item
152300
Protein
PDE3A
Organism
Human
Assay Sub Type
Enzymatic
Family
PDE
Name
PDE4D2 Human Phosphodiesterase Enzymatic LeadHunter Assay - TW
Item
154420
Protein
PDE4D
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
IR Human RTK Kinase Enzymatic Radiometric LeadHunter Assay [10 μM ATP] - TW
Item
174990
Protein
IR
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Lck Human TK Kinase Enzymatic Radiometric LeadHunter Assay [10 μM ATP] - TW
Item
176020
Protein
Lck
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
PKCalpha Human PKC Kinase Enzymatic Radiometric LeadHunter Assay [10 μM ATP] - TW
Item
180010
Protein
PKCa
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
A1 Human Adenosine GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
200510
Protein
A1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
A2A Human Adenosine GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
200610
Protein
A2A
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
Adenosine Human Transporter Binding Antagonist Radioligand LeadHunter Assay - TW
Item
202020
Protein
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha1A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
203110
Protein
alpha1A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha1B Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
203210
Protein
alpha1B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha1D Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
203400
Protein
alpha1D
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha2A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
203630
Protein
alpha2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha2B Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
203710
Protein
alpha2B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
beta1 Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
204010
Protein
beta1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
beta2 Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
204110
Protein
beta2
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
NET Human Norepinephrine Transporter Binding Antagonist Radioligand LeadHunter Assay - TW
Item
204410
Protein
NET
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
AR Human Androgen NHR Binding Agonist Radioligand LeadHunter Assay - TW
Item
206000
Protein
AR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
AT1 Human Angiotensin GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
210030
Protein
AT1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
B2 Human Bradykinin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
212620
Protein
B2
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav1.2 (L-type) Rat Calcium Ion Channel Binding (Diltiazem Site) LeadHunter Assay - TW
Item
214510
Protein
Cav1.2 (L-type)
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav1.2 (L-type) Human Calcium Ion Channel Binding (Dihydropyridine Site) LeadHunter Assay - TW
Item
214610
Protein
Cav1.2 (L-type)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav1.2 (L-type) Rat Calcium Ion Channel Binding (Verapamil Site) LeadHunter Assay - TW
Item
215000
Protein
Cav1.2 (L-type)
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav2.2 (N-type) Rat Calcium Ion Channel Binding Antagonist Radioligand LeadHunter Assay - TW
Item
216000
Protein
Cav2.2 (N-type)
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
CB1 Human Cannabinoid GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
217050
Protein
CB1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
217100
Protein
CB2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CCR1 Human Chemokine GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
217510
Protein
CCR1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CCK1 (CCKA) Human Cholecystokinin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
218030
Protein
CCK1 (CCKA)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CCK2 (CCKB) Human Cholecystokinin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
218130
Protein
CCK2 (CCKB)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D1 Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
219500
Protein
D1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D2L Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
219600
Protein
D2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D2S Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
219700
Protein
D2
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
DAT Human Dopamine Transporter Binding Antagonist Radioligand LeadHunter Assay - TW
Item
220320
Protein
DAT
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
ETA Human Endothelin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
224010
Protein
ETA
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
ERalpha Human Estrogen NHR Binding Agonist Radioligand LeadHunter Assay - TW
Item
226010
Protein
ERalpha
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
GABA (Non-Selective) Rat Transporter Binding Antagonist Radioligand LeadHunter Assay - TW
Item
226400
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (Non-Selective) Rat Ion Channel [3H] Flunitrazepam Binding Agonist Radioligand LeadHunter Assay - TW
Item
226600
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (Non-Selective) Rat Ion Channel [3H] Ro-15-1788 Binding (Hippocampus) LeadHunter Assay - TW
Item
226630
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (Non-Selective) Rat Ion Channel [3H] TBOB Binding Antagonist Radioligand LeadHunter Assay - TW
Item
226810
Protein
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
GABAB (B1a/B2) Human GABAB GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
228610
Protein
GABAB (B1/B2)
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
GR Human Glucocorticoid NHR Binding Agonist Radioligand LeadHunter Assay - TW
Item
232030
Protein
GR
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (AMPA, Non-Selective) Rat Ion Channel [3H] AMPA Binding LeadHunter Assay - TW
Item
232600
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (Kainate, Non-Selective) Rat Ion Channel [3H] Kainic acid Binding LeadHunter Assay - TW
Item
232710
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (NMDA, NR1/NR2A) Human Ion Channel [3H] CGP-39653 Binding LeadHunter Assay - TW
Item
232820
Protein
GluN1/ GluN2A
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (NMDA, Non-Selective) Rat Ion Channel [3H] MDL 105,519 Binding LeadHunter Assay - TW
Item
232910
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (Non-Selective) Rat Ion Channel [3H] TCP Binding LeadHunter Assay - TW
Item
233000
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (NMDA, Non-Selective) Rat Ion Channel [3H] Ifenprodil Binding LeadHunter Assay - TW
Item
234000
Protein
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
mGlu5 Human Glutamate (Metabotropic) GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
237000
Protein
mGlu5
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glycine alpha1 Human Ion Channel [3H] Strychnine Binding LeadHunter Assay - TW
Item
239010
Protein
GLRA1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
H1 Human Histamine GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
239610
Protein
H1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
H2 Human Histamine GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
239710
Protein
H2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CXCR2 (IL-8RB) Human Chemokine GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
244500
Protein
CXCR2 (IL-8RB)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CysLT1 Human Leukotriene GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
250460
Protein
CysLT1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
MC1 Human Melanocortin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
251100
Protein
MC1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
MC4 Human Melanocortin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
251350
Protein
MC4
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M1 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
252610
Protein
M1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M2 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
252710
Protein
M2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M3 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
252810
Protein
M3
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M4 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
252910
Protein
M4
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
NK1 Human Tachykinin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
255520
Protein
NK1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
Y1 Human Neuropeptide Y GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
257010
Protein
NPY1R
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
nAChR (alpha1) Human Ion Channel Binding Antagonist Radioligand LeadHunter Assay - TW
Item
258700
Protein
nAChR-a1
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
nAChR (alpha3/beta4) Human Ion Channel Binding Agonist Radioligand LeadHunter Assay - TW
Item
258730
Protein
nAChR-a3b4
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
delta (DOP) Human Opioid GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
260130
Protein
delta (DOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
kappa (KOP) Human Opioid GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
260210
Protein
kappa (KOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
mu (MOP) Human Opioid GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
260410
Protein
mu (MOP)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
KATP Hamster Potassium Ion Channel Binding Antagonist Radioligand LeadHunter Assay - TW
Item
265600
Protein
KATP
Organism
Hamster
Assay Sub Type
Binding
Family
Ion Channel
Name
hERG Human Potassium Ion Channel [3H] Dofetilide Binding Antagonist Radioligand LeadHunter Assay - TW
Item
265910
Protein
hERG
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
PPARgamma Human NHR Binding Agonist Radioligand LeadHunter Assay - TW
Item
267500
Protein
PPARgamma
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT1A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
271110
Protein
5-HT1A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT1B Human Serotonin GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
271230
Protein
5-HT1B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2A Human Serotonin GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
271650
Protein
5-HT2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2B Human Serotonin GPCR [3H] LSD Binding Agonist Radioligand LeadHunter Assay - TW
Item
271700
Protein
5-HT2B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2C Human Serotonin GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
271800
Protein
5-HT2C
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
5-HT3 Human Serotonin Ion Channel Binding Antagonist Radioligand LeadHunter Assay - TW
Item
271910
Protein
5-HT3A
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
SERT Human Serotonin Transporter Binding Antagonist Radioligand LeadHunter Assay - TW
Item
274030
Protein
SERT
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Nav1.5 Sodium Channel Human Ion Channel [3H]BNZA Binding LeadHunter Assay - TW
Item
279520
Protein
Nav1.5
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
V1A Human Vasopressin / Oxytocin GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
287530
Protein
V1A
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
PR Human Progesterone NHR Binding Agonist Radioligand LeadHunter Assay - TW
Item
299005
Protein
PR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
PAF Human Platelet-Activating Factor GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
299037
Protein
PAF
Organism
Human
Assay Sub Type
Binding
Assay Information
Assay Type:
Biochemical
Testing Information
Test Concentration / Dose:
Suggested concentration for initial testing is 10 µM
Test Sample Requirements:
150 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
SafetyScreen
Testing Location:
Taiwan - Taipei
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Item: PP241
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Item: PP323
SafetyScreenPLUS Panel - TW
Item: PP324
SafetyScreen33 Delta Panel - TW
Item: PP327
SafetyScreen77 Core Extended Panel - TW
Item: PP328
Questions? Contact Us
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