sigma1 Human Binding Agonist Radioligand LeadHunter Assay - FR

Background Information:

Sigma receptor-mediated transduction mechanisms have not as yet been fully elucidated, but require neither G-protein activation nor phosphorylation. Sigma receptors, located primarily in the central nervous system but also in endocrine and immune systems, have been implicated in psychosis, depression, cognition, neuroprotection, and locomotion in the central nervous system and regulation of cell proliferation. Sigma s1 receptors, at least in part, are intracellular amplifiers of glutaminergic NMDA, dopaminergic, IP3-related metabotropic, nerve growth factor-related systems, voltage-gated K+ channels as well as Ca2+influx and intracellular mobilization. Sigma s1 receptor agonist may be antidepressant, facilitate learning and addiction, and reduce opiate analgesia. Sigma s1 receptor antagonist may be antipsychotic.

Family:

Transmembrane (Other)

Sub Family:

Sigma

Protein Name:

sigma1

Uniprot Number:

Q99720

Gene Name:

SIGMAR1

Gene ID:

10280

Gene Aliases:

SR-BP1

Accession Number:

NM_005866

Organism:

Human