sst3 Human Somatostatin GPCR Cell Based Agonist cAMP LeadHunter Assay - TW

Background Information:

Somatostatin (somatotropin-release inhibiting factor, SRIF) receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The five known receptors can be divided into two groups: SRIF1 (SRIF1A=sst2, SRIF1B=sst5, srif1C=sst3) and SRIF2 (SRIF2A=sst1, srif2B=sst4); lower case (srif) indicates an as yet undefined physiological role. SRIF receptors are found in most peripheral tissues and within the central nervous sytem.

Family:

GPCR

Sub Family:

Somatostatin

Class:

Class A

Protein Name:

sst3

Uniprot Number:

P32745

Protein Aliases:

SS3-R|SS3R|SSR-28

Gene Name:

SSTR3

Gene ID:

6753

Accession Number:

XM_011530349

Organism:

Human

Construct Details:

Full Length, Recombinant

Cell Type:

CHO-K1