UT (GPR14) Human Urotensin GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Urotensin II receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Urotensin II receptors are found in the brain stem and spinal cord as well as peripheral tissue, especially heart and vasculature.
Family:
GPCR
Sub Family:
Urotensin
Class:
Class A
Protein Name:
UT (GPR14)
Uniprot Number:
Q9UKP6
Protein Aliases:
G-protein coupled receptor 14|Urotensin II receptor|UR-II-R
Gene Name:
UTS2R
Gene ID:
2837
Gene Aliases:
GPR14
Accession Number:
NM_018949
Organism:
Human
Construct Details:
Recombinant
Cell Type:
CHO-K1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist
Detection Method:
Fluorimetry
Measured Response:
Fluorescence
Testing Information
Incubation:
RT
Control Activator:
urotensin II
Test Concentration / Dose:
Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.
Test Sample Requirements:
Minimum for 1) Screen: 70 µL of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM finµL testing. 2) Dose Response: 90 µL of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
16
Turnaround Time
Standard:
15 Business Days
Reference Compound Data
Clinical Relevance
Therapeutic Area:
Cardiovascular
Adverse / Beneficial Action:
Urotensin II receptor agonism may contribute to impaired myocardial function, cause peripheral vasoconstriction as well as renal vasodilation with urinary water and sodium excretion.
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
UT (GPR14) Human Urotensin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item: 1386
UT (GPR14) Human Urotensin GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item: 1836
UT (GPR14) Human Urotensin GPCR Cell Based Agonist & Antagonist Calcium Flux LeadHunter Assay - FR
Item: G099
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