LeadHunter® Discovery Services offers a rapidly growing portfolio of cell-based kinase assays for detection of both Receptor Tyrosine Kinase (RTK) and Cytosolic Tyrosine Kinase (CTK) signaling. Our panel of over 100 kinase targets provides you with a comprehensive understanding of compound binding within the tyrosine kinase family. And our kinase panels allow you to test your compounds in a more physiological setting to determine inhibitor membrane permeability, competition in the presence of native ATP levels and effects under more physiologic conditions. The result: You can make more informed decisions about the therapeutic potential and off-target liabilities of your compounds.
Comprehensive Menu
Powered by the Eurofins Discovery PathHunter® technology, our comprehensive menu of receptor tyrosine kinase and cytosolic tyrosine kinase assays is designed for compound screening and profiling against high value kinase targets in the areas of oncology, neurological disorders, metabolic disease and inflammation. These fully optimized, target-validated assays allow you to study kinase activation, receptor internalization or screen for novel kinase inhibitors using a simple and quantitative chemiluminescent assay.
Panel Highlights and Benefit:
- Full length human kinases expressed in cells
- High-quality functional data – accurate, precise, and reproducible
- Flexible service options – either pre-defined panels or personalized assay selection
- Broad applications – primary screening, lead optimization and mechanism-of-action studies
- Agonist and antagonist modes available
- Rapid data turnaround time
Assay Principle
